The most typical causes of mixed hearing loss are the same as for conductive and sensorineural hearing loss, and include:
- Genetic factors
 - Aging; after age 65, one out of three people has hearing loss
 - Excessive noise, often from work or listening to loud music
 - Certain medications
 - Birth conditions
 - Tumors and diseases
 - Head trauma
 - Ear wax
 - Ear infections